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What is Lortab?
Lortab contains a combination of acetaminophen and hydrocodone. Hydrocodone is an opioid pain medication. An opioid is sometimes called a narcotic. Acetaminophen, also called Tylenol, is a less potent pain reliever that increases the effects of hydrocodone.
Lortab is used to relieve moderate to severe pain.
Lortab may also be used for purposes not listed in this medication guide.

Before taking Lortab
You should not use Lortab if you are allergic to acetaminophen (Tylenol) or hydrocodone, or if you have recently used alcohol, sedatives, tranquilizers, or other narcotic medications.

Do not use Lortab if you have taken a MAO inhibitor in the past 14 days. A dangerous drug interaction could occur. MAO inhibitors include isocarboxazid, linezolid, phenelzine, rasagiline, selegiline, and tranylcypromine.

Some medicines can interact with hydrocodone and cause a serious condition called serotonin syndrome. Be sure your doctor knows if you also take medicine for depression, mental illness, Parkinson's disease, migraine headaches, serious infections, or prevention of nausea and vomiting. Ask your doctor before making any changes in how or when you take your medications.

To make sure Lortab is safe for you, tell your doctor if you have:
liver disease, cirrhosis, or if you drink more than 3 alcoholic beverages per day;

a history of alcoholism or drug addiction;

diarrhea, inflammatory bowel disease, bowel obstruction, severe constipation;

kidney disease;
low blood pressure, or if you are dehydrated;
a history of head injury, brain tumor, or stroke;
asthma, COPD, sleep apnea, or other breathing disorders; or

if you use a sedative like Valium (diazepam, alprazolam, lorazepam, Ativan, Klonopin, Restoril, Tranxene, Versed, Xanax, and others).


Lortab is more likely to cause breathing problems in older adults and people who are severely ill, malnourished, or otherwise debilitated.


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