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Are we competent to take analgesics

Most people have no idea of the maximum daily dose of paracetamol. In the UK about one in four people frequently exceed the maximum daily dose (it’s 4,000mg, or eight tablets, by the way). In the US, half did not know the maximum daily dose, and one in 20 thought it as high as 10,000m

• Patients switching from regular oxycodone forms: Adults—One tablet every 12 hours. ...

• Patients switching from other narcotic medicines: Adults—One tablet every 12 hours. ...

• Patients who are not taking narcotic medicines: Adults—At first, 10 milligrams (mg) every 12 hours.

Sleep disorders are conditions that affect your ability to get the rest your body needs and maintain wakefulness. There are over 80 sleep disorders that impact:

• How well you sleep (quality).

• When you fall asleep and if you can stay asleep (timing).

• How much sleep and wakefulness you get (quantity or duration).

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  Safety boils down to examining really bad things happening to a very small number of people who take a drug. Unless the rate of the very bad thing is vanishingly small, the authorities won’t let us buy the drug from a petrol station. If we want to study those rare events, then we need study large numbers of people. Partly because paracetamol is such an old drug these studies have largely not been done until recently.